In her career, Zakopalová has reached eight singles finals and won two, both in 2005: on grass in Rosmalen (Netherlands) and in September in Portorož (Slovenia) on hard court.
In January 2006, she played a comeback player Martina Hingis, at the WTA Tournament in Gold Coast, Queensland, Australia, whom she lost to in the second round. Zakopalová was seeded No.29 at the 2006 Australian Open but lost in the first round to Ekaterina Bychkova of Russia. In that year, Klara had ten first-round losses in singles and failed to win a doubles match.
In 2008, Zakopalová reached the final of the inaugural Cachantun Cup in Chile. She played the top seed Flavia Pennetta but was forced to retire due to an ankle sprain. This also forced her to withdraw from the next tournament in Bogotá, where she had made the quarterfinals in 2007.
Zakopalová 's biggest win came at the 2009 Andalucia Tennis Experience in Marbella, Spain. She defeated World No. 1 and ten time grand slam champion Serena Williams, 6–4, 3–6, 6–1. Williams was also her first round opponent at the 2009 French Open, where Zakopalová lost 3–6, 7–6, 4–6.
Zakopalová gained another good win over a top 5 player, defeating Dinara Safina in the first round of the 2010 Mutua Madrilena Madrid Open 7–6(1), 7–6(3).
In the first round of the 2010 Polsat Warsaw Open, Zakopalova caused a big upset by defeating 4th seed and World No.14 Marion Bartoli 4–6, 6–1, 6–2. She was then defeated by World No.205 Gréta Arn in the second round 6–4, 6–4.
At the 2010 Wimbledon Championships, Zakopalova advanced to the 4th round for the first time at a Grand Slam. She scored upset wins over 18th seed Aravane Rezaï and 10th seed Flavia Pennetta before falling to qualifier Kaia Kanepi.
Zakopalova made the final at the 2010 e-Boks Danish Open where she lost to World No. 3 Caroline Wozniacki. Zakopalova defeated Rossana De Los Rios, Tatjana Malek, Sorana Cîrstea, and Li Na en route to the final. After this tournament, could not match up her performance as she went on to do poorly her last four tournaments, only advancing to the second round in the 2010 Generali Ladies Linz where she lost to Patty Schnyder 6–2, 6–0.
On 6 June 2006, Klara married Czech soccer player, Jan Zakopal[1] (born 22 October 1977 in Zlín), who played five times for the Czech Republic national under-20 football team in 1997 while he was a player of Sparta Prague,[3] and who previously had played for FC Zlín and Dukla Příbram,[4] and later played for SK Chrudim, Tatran Poštorná, FK Viktoria Žižkov, SK České Budějovice and FC Viktoria Plzeň.
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